Сonnection of immunological markers with morphological manifestations in ulcerative colitis

Background. Inflammatory bowel diseases, including ulcerative colitis and Crohn’s disease, are an urgent problem of modern gastroenterology. Therefore, the discovery new laboratory approaches makes it possible to assess degree disease. Purpose: reveal relationship between morphological manifestations immunological indicators in patients with colitis. Materials methods. The studies were conducted on biological material (blood colonic biopsy samples) 90 thickness mucosa, density inflammatory infiltrate its composition, crypt sizes, their architectonics, presence abscesses, atrophic fibrotic changes calculated biopsies by morphometric Immunological included evaluation mononuclear cells, levels B-lymphocytes, interleukin-10, tumor necrosis factor α, immunoglobulins (Ig) A, M, G. Results. histological activity disease was determined increased level (14,431.4 ± 483.3 per 1 mm2 stroma) many neutrophilic granulocytes (212.2 20.9 lymphocytes (2,922.8 76.6 it. Also, some had abscesses (36.7 % total number patients) breaches epithelial integrity (54.4 patients). A correlation found CD22+ parameters: width crypts (r = 0.27; P < 0.01) height surface epithelium 0.30; 0.01); IgM concentrations cellular mucosal 0.29; 0.01), neutrophils 0.28; basophils 0.24; 0.05); IgA macrophages 0.21; 0.05), 0.25; 0.05). Conclusions. It is shown that related parameters. elevated cytokines correlates inflammation (crypt height) directly increase processes intestinal mucosa.